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Widespread News coverage of Breast Cancer discovery published in Nature.

Marco Marra, director of the Michael Smith Genome Sciences Centre, was interviewed on CBC, Global TV and CTV. Additionally, many newspapers around the world reported this major advance in cancer research. The study published in Nature was funded by the BC Cancer Foundation; Canadian Breast Cancer Foundation, BC/Yukon region; Canadian Institutes for Health Research; Genome Canada; Genome BC; the Canada Foundation for Innovation; the Michael Smith Foundation for Health Research; and the National Cancer Institute, USA.

A Cancer Evolves

Breast Cancer Research published in Nature October 8, 2009

Scientists from several research departments within the BC Cancer Agency including the Michael Smith Genome Sciences Centre; Molecular Oncology; Centre for Translational and Applied Genomics; Medical Oncology; and the Deeley Research Centre, along with colleagues from the University of British Columbia (Department of Pathology) and Cancer Research UK have had their ground breaking research published in the prestigious scientific journal Nature. According to the findings, primary breast cancers acquire new mutations in their protein coding regions as they progress towards metastasis. The research team sequenced the genome and transcriptome of a metastatic breast cancer at high depth, using the Illumina Genome Analyzer GAiix platform, and analyzed the data for somatic coding mutations. The findings have an impact on the understanding of heterogeneity in cells at tumour sites and the evolution of cancer.

The full scientific paper, "Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution" is available on-line.

Drs. Marco Marra and Sam Aparicio, the lead scientists on this project, were interviewed by CTV News, Global TV, the CBC National and CBC News website.

Articles reporting on the significance of this research have also been published in the Vancouver Sun, the Province, the Globe and Mail, CanWest News Service, LA Times, Triangle Business Journal, and Reuters

Page last modified Oct 09, 2009