Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells
Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization.
Macroautophagy (autophagy), a process for lysosomal degradation of organelles and long-lived proteins, has been linked to various pathologies including cancer and to the cellular response to anticancer therapies. In this study, our findings indicate that autophagy has a primary pro-survival role following tamoxifen treatment, and suggest that autophagy knockdown may be useful in a combination therapy setting to sensitize breast cancer cells, including tamoxifen-resistant breast cancer cells, to tamoxifen therapy.
Full citation
Qadir MA, Kwok B, Dragowska WH, To KH, Le D, Bally MB, Gorski SM. Breast Cancer Research and Treatment 2008 Jan 3 [Epub ahead of print].
Further details of this publication can be found online at:
http://www.ncbi.nlm.nih.gov/pubmed/18172760
For more information please contact info@bcgsc.ca
Full citation
Qadir MA, Kwok B, Dragowska WH, To KH, Le D, Bally MB, Gorski SM. Breast Cancer Research and Treatment 2008 Jan 3 [Epub ahead of print].
Further details of this publication can be found online at:
http://www.ncbi.nlm.nih.gov/pubmed/18172760
For more information please contact info@bcgsc.ca
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Jul 25, 2008