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Rebuilding microbial genomes

Rebuilding microbial genomes.
Re: PublicationCells can be built from scratch by assembling small molecule sets with auto-catalytic properties. Alternatively,
DNA can be isolated or directly synthesized and molded into a synthetic genome using existing genomic blueprints and molecular biology tools. Activating such a synthetic genome will yield a synthetic cell.  In this publication we examine obstacles associated with this latter approach using a model system whereby a donor genome from H. influenzae is fragmented, and the pieces are then modified and reassembled stepwise in an E. coli host cell.

Full citation

Holt Ra, Warren R, Flibotte S, Missirlis PI & Smailus DE.  Bioessays 2007.  29(6):580-590.

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Page last modified Jul 28, 2008