ChIP-seq for STAT1 in HeLa cells
Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing.
This work demonstrated a new technique for detecting where proteins that control gene expression are bound to DNA, and the manuscript showed that the new technique was accurate. Such technology will be key in furthering our understanding of the complex genetic networks that are activated during the progression of cancer.
Full citation
Robertson G, Hirst M, Bainbridge M, Bilenky M, Zhao Y, Zeng T, Euskirchen G, Bernier B, Varhol R, Delaney A, Thiessen N, Griffith OL, He A, Marra M, Snyder M, Jones S. Nature Methods 2007. 4(8):651-657.
Further details of this publication can be found online ate:
http://www.ncbi.nlm.nih.gov/pubmed/17558387?ordinalpos=4For more information please contact info@bcgsc.ca
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Jul 28, 2008