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You are here: Home / Faculty / Dr. Gregg B. Morin, PhD / Publications Complete

Complete Publications of Dr. Gregg Morin

Gregg Morin's Complete Bibliography (Updated February 2018)
  1. Owen DR, Wong HL, Bonakdar M, Jones M, Hughes CS, Morin GB, Jones SJM, Renouf DJ, Lim H, Laskin J, Marra M, Yip S, Schaeffer DF. Molecular characterization of ERBB2-amplified colorectal cancer identifies potential mechanisms of resistance to targeted therapies: A report of two instructive cases. Cold Spring Harbor Molecular Case Studies. 2018 Feb 8. pii: mcs.a002535. doi: 10.1101/mcs.a002535. [Epub ahead of print]
  2. Lai D, Chen M, Su J, Liu X, Rothe K, Hu K, Forrest DL, Eaves CJ, Morin GB, Jiang X.  PP2A inhibition sensitizes cancer stem cells to ABL tyrosine kinase inhibitors in BCR-ABL+ human leukemia.  Science Translational Medicine. 2018 Feb 7;10(427). pii: eaan8735. PMID: 29437150
  3. Mathew V, Tam AS, Milbury KL, Hofmann AK, Hughes CS, Morin GB, Loewen CJR, Stirling PC.  Selective aggregation of the splicing factor Hsh155 suppresses splicing upon genotoxic stress. Journal of Cell Biology.  2017 Dec 4;216(12):4027-40.
  4. Hughes CS, Morin GB.  Using Public Data for Comparative Proteome Analysis in Precision Medicine Programs. Proteomics Clinical Applications.  2017 Sep 9. doi: 10.1002/prca.201600179. [Epub ahead of print]
  5. Choutka C, DeVorkin L, Go NE, Hou YC, Moradian A, Morin GB, Gorski SM. Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy.  Autophagy. 2017 Sep 2;13(9):1573-1589.
  6. Wang Y, Chen SY, Karnezis AN, Colborne S, Santos ND, Lang JD, Hendricks WPD, Orlando KA, Yap D, Kommoss F, Bally MB, Morin GB, Trent JM, Weissman BE, Huntsman DG. The histone methyltransferase EZH2 is a therapeutic target in small cell carcinoma of the ovary, hypercalcemic type. Journal of Pathology. 2017 Jul;242(3):371-383.
  7. Hughes CS, Spicer V, Krokhin O, Morin GB. Investigating Acquisition Performance on the Orbitrap Fusion when using Tandem MS/MS/MS Scanning with Isobaric Tags. Journal of Proteome Research. 2017 May 5;16(5):1839-1846.
  8. Hughes CS, Zhu C, Spicer V, Krokhin O, Morin GB. Evaluating the Characteristics of Reporter Ion Signal Acquired in the Orbitrap Analyzer for Isobaric Mass Tag Proteome Quantification Experiments. Journal of Proteome Research.  2017 May 5;16(5):1831-1838.
  9. Tien JF, Mazloomian Cheng SWG, Hughes CS, Chow CCT, Canapi LT, Oloumi A, Trigo-Gonzalez G, Bashashati A, Xu J, Chang VCD, Shah SP, Aparicio S, Morin GB.  CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.  Nucleic Acids Research. 2017;45(11):6698-6716.
  10. Funnell T, Tasaki S, Oloumi A, Araki S, Kong E, Yap D, Nakayama Y, Hughes CS, Cheng SWG, Tozaki H, Iwatani M, Sasaki S, Ohashi T, Miyazaki T, Morishita N, Morishita D, Ogasawara-Shimizu M, Ohori M, Nakao S, Karashima M, Sano M, Murai A, Nomura T, Uchiyama N, Kawamoto T, Hara R, Nakanishi O, Shumansky K, Rosner J, Wan A, McKinney S, Morin GB, Nakanishi A, Shah S, Toyoshiba H, Aparicio S. Transcriptome dynamics of CLK dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.  Nature Communications. 2017;8(1):7.
  11. Hughes CS, McConechy MK, Cochrane DR, Nazeran T, Karnezis AN, Huntsman DG, Morin GB.  Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research. Scientific Reports. 2016 Oct 7;6:34949.
  12. Barakauskas VE, Moradian A, Barr AM, Beasley CL, Rosoklija G, Mann JJ, Ilievski B, Stankov A, Dwork AJ, Falkai P, Morin GB, Honer WG. Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia. Schizophrenia Research. 2016 Nov;177(1-3):44-51.
  13. Dixon-Clarke SE, Elkins JM, Cheng SWG, Morin GB, Bullock AN.  Structures of the CDK12-cyclin K complex reveal a flexible C-terminal kinase extension important for ATP binding.  Scientific Reports. 2015 Nov 24;5:17122.
  14. Chen J, Wang Y, McMonechy MK, Anglesio MS, Yang W, Senz J, Maines-Bandiera S, Rosner J, Trigo-Gonzalez G, Grace Cheng SW, Kim J, Matzuk MM, Morin GB, Huntsman DG. Recurrent DICER1 Hotspot Mutations in Endometrial Tumours And Their Impact on MicroRNA Biogenesis. Journal of Pathology. 2015 Oct;237(2):215-25.
  15. Wang Y, Chen J, Yang W, Mo F, Senz J, Yap D, Anglesio MS, Gilks B, Morin GB, Huntsman DG.  The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors.  Neoplasia.  2015 Aug;17(8):650-60.
  16. Pon JR, Wong J, Saberi S, Alder O, Moksa M, Grace Cheng SW, Morin GB, Hoodless PA, Hirst M, Marra MA.  MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation. Nature Communications. 2015 Aug 6;6:7953.
  17. Chittaranjan S, Xu J, Dullat HK, Wilton J, DeVorkin L, Lebovitz C, Morin GB, Marra MA, Gorski SM.  The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy. Biology Open. 2015 Apr 2;4(5):672-84.
  18. Gibb EA, Warren RL, Wilson GW, Brown SD, Robertson G, Morin GB*, Holt RA*. Activation of an endogenous retroviral-associated long non-coding RNA in human adenocarcinoma.  Genome Medicine. 2015 Mar 5;7(1):22.  (*co-corresponding author)
  19. Chittaranjan S, Chan S, Yang C, Yang K, Chen V, Moradian A, Firme M, Song J, Go N, Blough M, Chan JA, Cairncross G, Gorski SM, Morin GB, Yip S, Marra MA.  Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity.  Oncotarget. 2014 Sep 15;5(17):7960-79.
  20. Berg T, Thoene S, Yap D, Wee T, Schoeler N, Rosten P, Lim E, Bilenky M, Mungall AJ, Oellerich T, Lee S, Lai CK, Umlandt P, Salmi A, Chang H, Yue L, Lai D, Chen G, Morin RD, Hirst M, Serve HS, Marra MA, Morin GB, Gascoyne RD, Aparicio SA, Humphries RK.  A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.  Blood. 2014 Jun 19;123(25):3914-24.
  21. DeVorkin L, Go NE, Hou YC, Moradian A, Morin GB, Gorski SM. The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB.  Journal of Cell Biology.  2014 May 26;205(4):477-492.
  22. Premkumar V, Linger BR. Cranert S, Morin GB, Minium S, Price C. The 3’ overhangs at Tetrahymena telomeres are packaged by four proteins: Pot1a, Tpt1, Pat1 and Pat.  Eukaryotic Cell. 2014 Feb;13(2):240-5.
  23. Griffith M, Paul JE, Pugh TJ, Tang MJ, Morin RD, Asano JK, Ally AA,  Miao L, Cheung P, Lee A, Chan SY, Taylor G, Severson R, Hou YC, Griffith OL, Cheng G, Novik K, Moore R, Luk M, Owen D, Brown C, Morin GB, Gill S, Tai I, Marra MA. Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer. Pharmacogenomics J. 2013 Apr;13(2):148-58.
  24. Anglesio MS, Wang Y, Yang W, Senz J, Wan A, Heravi-Moussavi A, Salamanca C, Maines-Bandiera S, Huntsman DG, Morin GB.  Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.  Journal of Pathology. 2013 Feb;229(3):400-9.
  25. van Wietmarschen N, Moradian A, Morin GB, Lansdorp PM, and Uringa E-J.  The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly.  J. Biol. Chem. 2012 Dec 21;287(52):43351-8.
  26. Cheng SW, Kuzyk MA, Moradian A, Ichu TA, Chang VC, Tien JF, Vollett SE, Griffith M, Marra MA, Morin GB.  The interaction of CDK12/CrkRS with CYCLIN K1 is required for the phosphorylation of the C-terminal domain of RNA Pol II.  Mol Cell Biol. 2012 Nov;32(22):4691-704.
  27. Liu X, Chen M, Lobo P, An J, Grace Cheng SW, Moradian A, Morin GB, Van Petegem F, Jiang X.  Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors.  Proteomics. 2012 Jul;12(13):2094-106.
  28. Shah SP, Roth A, Goya R, Oloumi A, Ha G, Zhao Y, Turashvili G, Ding J, Tse K, Haffari G, Bashashati A, Prentice L, Khattra J, Burleigh A, Yap D, Bernard V, McPherson A, Shumansky K, Crisan A, Giuliany R, Heravi-Moussavi A, Rosner J, Lai D, Birol I, Varhol R, Tam A, Dhalla N, Zeng T, Ma K, Chan S, Griffith M, Moradian A, Cheng SWG, Morin GB, Watson P, Gelmon K, Chia S, Chin SF, Curtis C, Rueda O, Pharoah P, Damaraju S, Mackey J, Hoon K, Harkins T, Tadigotla V, Sigaroudinia M, Gascard P, Tlsty T, Costello J, Meyer IM, Eaves CJ, Wasserman WW, Jones SJ, Huntsman D, Hirst M, Caldas C, Marra MA, Aparicio S. The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature. 2012 Apr 4;486(7403):395-9.
  29. Tognon CE, Martin MJ, Moradian A, Trigo G, Rotblat B, Cheng SW, Pollard M, Uy E, Chow C, Carboni JM, Gottardis MM, Pollak M, Morin GB, Sorensen PH. A tripartite complex composed of ETV6-NTRK3, IRS1 and IGF1R is required for ETV6-NTRK3-mediated membrane localization and transformation.  Oncogene. 2012 Mar 8;31(10):1334-40.
  30. Heravi-Moussavi A, Anglesio MS, Cheng SW, Senz J, Yang W, Prentice L, Fejes AP, Chow C, Tone A, Kalloger SE, Hamel N, Roth A, Ha G, Wan AN, Maines-Bandiera S, Salamanca C, Pasini B, Clarke BA, Lee AF, Lee CH, Zhao C, Young RH, Aparicio SA, Sorensen PH, Woo MM, Boyd N, Jones SJ, Hirst M, Marra MA, Gilks B, Shah SP, Foulkes WD, Morin GB, Huntsman DG. Recurrent Somatic DICER1 Mutations in Nonepithelial Ovarian Cancers. New England Journal of Medicine. 2012 Jan 19;366(3):234-42.
  31. Yip S, Butterfield YS, Morozova O, Chittaranjan S, Blough MD, An J, Birol I,  Chesnelong C, Chiu R, Chuah E, Corbett R, Docking R, Firme M, Hirst M, Jackman S, Karsan A, Li H, Louis DN, Maslova S, Moore R, Moradian A, Mungall K, Perizzolo M, Qian J, Roldan G, Smith EE, Tamura-Wells J, Thiessen N, Varhol R, Weiss S, Wu W, Young S, Zhao Y, Mungall A, Morin GB, Chan JA, Cairncross JG, Marco MA. Concurrent CIC mutations, IDH mutations and 1p/19q loss distinguish oligodendrogliomas from other cancers. Journal of Pathology. 2012 Jan;226(1):7-16.
  32. Linger BR, Morin GB, and Price CM. The Pot1a-associated proteins Tpt1 and Pat1 coordinate telomere protection and length regulation in Tetrahymena, Mol Biol Cell. 2011 Nov;22(21):4161-70. 
  33. McConechy MK,  Anglesio MS, Kalloger SE, Yang W, Senz J, Chow C, Heravi-Moussavi A, Morin GB, Mes-Masson AM, Australian Ovarian Cancer Study Group, Carey MS, McAlpine JN, Kwon JS, Prentice LM, Boyd N, Shah SP, Gilks CB, Huntsman DG.  Subtype specific mutation of PPP2R1A in endometrial and ovarian carcinomas. Journal of Pathology. 2011Apr; 223(5):567-73.
  34. Yap DB, Chu J, Berg T, Schapira M, Cheng SWG, Moradian A, Morin R, Mungall A, Meissner B, Boyle M, Marquez V, Marra M, Gascoyne R, Humphries R, Arrowsmith C, Morin GB, and Aparicio S. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood. 2011 Feb 24;117(8):2451-9.
  35. Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T, Senz J, McConechy MK, Anglesio MS, Kalloger SE, Yang W, Heravi-Moussavi A, Giuliany R, Chow C, Fee J, Zayed A, Prentice L, Melnyk N, Turashvili G, Delaney AD, Madore J, Yip S, McPherson AW, Ha G, Bell L, Fereday S, Tam A, Galletta L, Tonin PN, Provencher D, Miller D, Jones SJ, Moore RA, Morin GB, Oloumi A, Boyd N, Aparicio SA, Shih IeM, Mes-Masson AM, Bowtell DD, Hirst M, Gilks B, Marra MA, Huntsman DG. ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med. 2010 Oct 14;363(16):1532-1543.
  36. Griffith M, Griffith O, Mwenifumbo J, Goya R, Morrissy S, Morin RD, Corbett R, Tang MJ, Hou YC, Pugh TJ, Robertson G, Chittaranjan S, Ally A, Asano JK, Chan SY, Li HI, McDonald H, Teague K, Zhao Y, Zeng T, Delaney A, Hirst M, Morin GB, Jones SJM, Tai IT, Marra MA. Alternative expression analysis by RNA sequencing. Nature Methods. 2010 Oct 7;7(10):843-7.
  37. Mead CR, Kuzyk MA, Moradian A, Wilson GM, Holt RA, Morin GB. Cytosolic Protein Interactions of the Schizophrenia Susceptibility Gene Dysbindin. Journal of Neurochemistry, 2010 March; 113:1491-1503.
  38. Griffith M, Tang MJ, Griffith OL, Chan SY, Asano JK, Zeng T, Flibotte S, Ally A, Baross A, Morin RD, Hirst M, Jones SJM, Morin GB, Tai IT and Marra MA.  ALEXA – A microarray design platform for alternative expression analysis. Nature Methods. 2008 Feb;5(2):118.
  39. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D.  Large-scale mapping of human protein-protein interactions by mass spectrometry, Mol Syst Biol. 2007 March 13;3:89.
  40. Colwill K, Wells CD, Elder K, Goudreault M, Hersi K, Kulkarni S, Hardy WR, Pawson T, and Morin GB.  Modification of the Creator Recombination System for Proteomics Applications - Improved Expression by Addition of Splice Sites, BMC Biotechnology. 2006 Mar 6;6(1):13.
  41. Allsopp RC, Morin GB, DePinho RA, Harley CB, Weissman IL.  Telomerase is required to slow telomere shortening and extend replicative lifespan of HSC during serial transplantation, Blood. (2003A) Jul 15;102(2):517-20.
  42. Allsopp RC, Morin GB, Horner JW, DePinho RA, Harley CB, Weissman IL.   Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells, Nature Medicine. (2003B) Apr;9(4):369-71.
  43. Kaminker PG, Kim SH, Taylor RD, Zebarjadian Y, Funk WD, Morin GB, Yaswen P and Campisi J. TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon over expression, J. Biol. Chem.  2001 Sep 21;276(38):35891-9.
  44. Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Oullette M, Trager JB, Morin GB, Toft DO, Shay JW, Wright WE, White MA.  Functional Requirement of p23 and hsp90 in Telomerase Complexes. Genes and Development 1999 Apr 1;13(7):817-26.
  45. Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA.  Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene.  1999 Feb 4;18(5):1219-26.
  46. Greenberg RA, Allsopp RC, Chin L, Morin GB*, DePinho RA*. Expression of mouse telomerase reverse transcriptase during development, differentiation, and proliferation. Oncogene.   (*co-corresponding author) 1998 Apr 2;16(13):1723-30.
  47. Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay SW, Lichtsteiner L, Wright WE.  Extension of life-span by introduction of telomerase into normal human cells. Science.  1998 Jan 16;279(5349):349-52
  48. Weinrich, SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, Harley CB, Morin GB. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nature Genetics.  1997 Dec;17(4):498-502.
  49. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science.  1997 Aug 15;217(5328):955-9.
  50. Morin GB. Recognition of a Chromosome Truncation Site Associated with α-Thalassaemia by Human Telomerase. Nature.  1991 Oct 3;353(6343):454-6.
  51. Morin GB. The Human Telomere Terminal Transferase is a Ribonucleoprotein that Synthesizes TTAGGG Repeats. Cell.  1989 Nov 3;59(3):521-9.
  52. Yarus M, Levine J, Morin GB, and Cech TR.  A Tetrahymena Intron Nucleotide Connected to the GTP/Arginine Site. Nucleic  Acids Res. 1989 Sep 12;17(17):6969-81.
  53. Morin GB, and Cech TR.  Telomeric Repeats of Tetrahymena malaccensis Mitochondrial DNA: a Multimodal Distribution that Fluctuates Erratically during Growth. Mol. Cell. Biol.  (1988C) Oct;8(10):4450-8.
  54. Morin GB, and Cech TR. Mitochondrial Telomeres: Surprising Diversity of Repeated Telomeric DNA Sequences among Six Species of Tetrahymena. Cell. (1988B) Feb12;52(3):367-74.
  55. Morin GB, and Cech TR. Phylogenetic Relationships and Altered Genome Structures among Tetrahymena Mitochondrial DNAs. Nucleic Acids Res.  (1988A) Jan 11; 16(1):327-46. 
  56. Morin GB, and Cech TR. The Telomeres of the Linear Mitochondrial DNA of Tetrahymena thermophila Consist of 53 bp Tandem Repeats. Cell.  1986 Sep12;46(6):873-83.
  57. Mohrig JR, Schultz SC, and Morin G.  Syn and Anti Stereochemistry in Elimination Reactions Producing Acyclic Conjugated Thioesters. J. Am. Chem. Soc.  1983;105:5150-5151. 
Page last modified Feb 14, 2018