Complete Publications of Dr. Sharon M. Gorski

Sharon Gorski's Complete Bibliography. (Updated February 2018)
  1. Yang KC, Sathiyaseelan P, Ho C, Gorski SM. Evolution of tools and methods for monitoring autophagic flux in mammalian cells. Biochemical Society Transactions. 2018 Jan 5. [Epub ahead of print] Review.
  2. †Wong HL, †Yang KC, †Shen Y, Zhao EY, Loree JM, Kennecke HF, Kalloger SE, Karasinska JM, Lim HJ, Mungall AJ, Feng X, Davies JM, Schrader K, Zhou C, Karsan A, Jones SJ, Laskin J, Marra MA, Schaeffer DF, Gorski SM, Renouf DJ. † Equal Contribution. Molecular characterisation of metastatic pancreatic neuroendocrine tumours (PNETs) using whole genome and transcriptome sequencing. Cold Spring Harbor Molecular Case Studies. 2017 Nov 1. [Epub ahead of print]
  3. Choutka C, DeVorkin L, Go NE, Hou YC, Moradian A, Morin GB, Gorski SM. Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy.  Autophagy. 2017 Sep 2;13(9):1573-89
  4. Bortnik S, Choutka C, Horlings HM, Leung S, Dragowska WH, Bally MB, Gelmon KA, Gorski SM. Identification of breast cancer cell subtypes sensitive to ATG4B inhibition.  Oncotarget. 2016 Oct 11;7(41):66970-88.
  5. Klionsky DJ, Abdelmohsen K, Abe A, ...[730 others], Gorski SM, ...[1732 others], Zughaier SM.  Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.
  6. Lebovitz CB, DeVorkin L, Bosc D, Rothe K, Singh J, Bally M, Jiang X, Young RN, Lum JJ, Gorski SM. Precision autophagy: Will the next wave of selective autophagy markers and specific autophagy inhibitors feed clinical pipelines? Autophagy. 2015 Oct 3;11(10):1949-52.  (Meeting report)
  7. Lebovitz CB, Robertson AG, Goya R, Jones SJ, Morin RD, Marra MA, Gorski SM.  Cross-cancer profiling of molecular alterations within the human autophagy interaction network. Autophagy. 2015 Sep 2;11(9):1668-87.
  8. Puleston D, Phadwal K, Watson AS, Soilleux EJ, Chittaranjan S, Bortnik S, Gorski SM, Ktistakis N, Simon AK. Techniques for the Detection of Autophagy in Primary Mammalian Cells. Cold Spring Harbor Protocols. 2015 Sep 1;2015(9):pdb.top070391.
  9. Chittaranjan S, Bortnik S, Gorski SM.  Monitoring Autophagic Flux by Using Lysosomal Inhibitors and Western Blotting of Endogenous MAP1LC3B. Cold Spring Harbor Protocols. 2015 Aug 3;2015(8):pdb.prot086256.
  10. Chittaranjan S, Xu J, Dullat HK, Wilton J, DeVorkin L, Lebovitz C, Morin GB, Marra MA, Gorski SM.  The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy.  Biology Open.  2015 Apr 2;4(5):672-84.
  11. DeVorkin L, Gorski SM. A mitochondrial-associated link between an effector caspase and autophagic flux.  Autophagy.  2014 Oct 1;10(10):1866-1867.
  12. Chittaranjan S, Chan S, Yang C, Yang K, Chen V, Moradian A, Firme M, Song J, Go N, Blough M, Chan JA, Cairncross G, Gorski SM, Morin GB, Yip S, Marra MA.  Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity.  Oncotarget. 2014 Sep 15;5(17):7960-79.
  13. DeVorkin L, Gorski SM. Genetic manipulation of autophagy in the Drosophila ovary. Cold Spring Harbor Protocols. 2014 Sep 2;2014(9):pdb.prot080358.
  14. DeVorkin L, Gorski SM. Monitoring Autophagy in Drosophila Using Fluorescent Reporters in the UAS-GAL4 System. Cold Spring Harbor Protocols. 2014 Sep 2;2014(9):pdb.prot080341.
  15. DeVorkin L, Gorski SM. Monitoring Autophagic Flux Using Ref(2)P, the Drosophila p62 Ortholog. Cold Spring Harbor Protocols. 2014 Sep 2;2014(9):pdb.prot080333.
  16. DeVorkin L, Gorski SM. LysoTracker Staining to Aid in Monitoring Autophagy in Drosophila. Cold Spring Harbor Protocols. 2014 Sep 2;2014(9):pdb.prot080325.
  17. Chittaranjan S, Bortnik S, Dragowska V, Xu J, Abeysundra N, Leung A, Erro Go N, DeVorkin L, Weppler S, Gelmon K, Yapp D, Bally M, Gorski SM.  Autophagy inhibition augments the anticancer effects of epirubicin treatment in anthracycline-sensitive and resistant triple negative breast cancer.  Clinical Cancer Research.  2014 Jun 15;20(12):3159-73.
  18. Rothe K, Lin H, Lin KB, Leung A, Wang HM, Malekesmaeili M, Brinkman RR, Forrest DL, Gorski SM, Jiang X.  The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem/progenitor cells.  Blood. 2014 Jun 5;123(23):3622-34.
  19. DeVorkin L, Go NE, Hou YC, Moradian A, Morin GB, Gorski SM. The Drosophila effector caspase Dcp-1 regulates mitochondrial dynamics and autophagic flux via SesB.  Journal of Cell Biology. 2014 May 26;205(4):477-492.
  20. DeVorkin L, Choutka C, Gorski SM. The interplay between autophagy and apoptosis. Book Chapter for “Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, and Infection. Volume 3.” Editor E. Hayat, Elsevier Publishing. January 2014.
  21. Jardon MA, Rothe K, Bortnik S, Vezenkov L, Jiang X, Young RN, Lum JJ, Gorski SM.  Autophagy: From structure to metabolism to therapeutic regulation.  Autophagy. 2013 Dec;9(12):2180-2.
  22. Dragowska WH, Weppler SA, Wang JC, Wong LY, Kapanen AI, Qadir MA, Donohue E, Roberge M, Gorski SM, Gelmon KA, Bally MB.  Induction of Autophagy is an Early Protective Response to Gefitinib Treatment in Breast Cancer Cells.  PLoS One. 2013 Oct 11;8(10):e76503.
  23. The Cancer Genome Atlas Research Network. Integrative analysis of genomic and molecular alterations in clear cell renal carcinoma. Nature. 2013 Jul 4; 499(7456): 43-9.
  24. Phan L and Gorski SM. Tamoxifen and Autophagy: to cease and resist. Chapter III in Tamoxifen Concepts and Cancer: New Paradigms, Nova Science Publishers, Inc., 2013.
  25. Spowart JE, Townsend KN, Huwait H, Eshragh S, West NR, Ries JN, Kalloger S, Anglesio M, Gorski SM, Watson PH, Gilks CB, Huntsman DG, Lum JJ.  The Autophagy Protein LC3A Correlates with Hypoxia and is a Prognostic Marker of Patient Survival in Clear Cell Ovarian Cancer.  J Pathol.  2012 Dec;228(4):437-47.
  26. Gorski SM, Ries J and Lum JJ. Targeting Autophagy – the Achilles’ heel of cancer. Autophagy. 2012 Aug;8(8):1279-80.
  27. Jardon M, Sattha B, Braasch K, Leung A, Côte H C.F, Butler M, Gorski SM, Piret J.M. Inhibition of glutamine-dependent autophagy increases t-PA production in CHO cell fed-batch processes. Biotechnol Bioeng. 2012 May;109(5):1228-38.

  28. Klionsky DJ, Abdalla FC, ...[373 others], Gorski SM, ...[893 others], Zuckerbraun B. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr;8(4):445-544.

  29. Lebovitz CB, Bortnik SB and Gorski SM. Here there be dragons: Charting autophagy-related alterations in human tumors. Clinical Cancer Research. 2012 Mar 1;18(5):1214-26.
  30. Armstrong LJ and Gorski SM. Breast Cancer and Autophagy. Chapter II in Breast Cancer: Causes, Diagnosis and Treatment, Nova Science Publishers, Inc., 2010.
  31. Chittaranjan S, McConechy M, Hou YC, Freeman JD, DeVorkin L and Gorski SM. Steroid hormone control of cell death and cell survival: molecular insights using RNAi. Plos Genetics. 2009, 5(2) e/000379.
  32. Hannigan AM, Gorski SM. Macroautophagy: The key ingredient to a healthy diet? Autophagy. 2009 Feb 3;5(2): 140-51.
  33. Hou YC, Hannigan AM, Gorski SM. An executioner caspase regulates autophagy. Autophagy. 2009 May;5(4):530-3.
  34. Hou YC, Chittaranjan S, Gonzalez S, McCall K and Gorski SM. Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila oogenesis. The Journal of Cell Biology. 2008 Sept. 22;182(6):1127-39.
  35. Qadir M, Kwok B, Dragowska WH, To KH, Le D, Bally MB, and Gorski SM. Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization. Breast Cancer Research and Treatment. 2008 Dec;112(3):389-403.
  36. Klionsky DJ, Abeliovich H, ...[71 others], Gorski SM, ...[161 others], Deter RL. Guidelines for Monitoring Autophagy in Higher Eukaryotes. Autophagy. 2008 Feb;4(2): 151-75. (multi-author/institution review)
  37. Copeland JM, Bosdet I, Guo M, Freeman JD, Guo M, Gorski SM* and Hay BA. Echninus, required for interommatidial cell sorting and cell death in the Drosophila pupal retina, encodes a protein with homology to ubiquitin-specific proteases. BMC Developmental Biology. 2007 Jul 5;7:82. *Co-corresponding author
  38. Akdemir F, Farkas R, Chen P, Juhasz G, Medvedova L, Sass M, Wang L, Wang X, Chittaranjan S, Gorski SM, Rodriguez A, Abrams JM. Autophagy occurs upstream of or parallel to the apoptosome during histolytic cell death. Development. 2006 Apr;133(8): 1457-65.
  39. Riddle DL and Gorski SM. Shaping and stretching life by autophagy. Preview, Developmental Cell. 2003 Sep;5(3):364-5.
  40. Sun Y, Kanekar SL, Vetter ML, Gorski SM, Jan YN, Glaser T, and Brown NL. Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evolution and Development. 2003 Sep-Oct;(5):532-41.
  41. Gorski SM, Chittaranjan S, Pleasance ED, Freeman JD, Anderson CL, Varhol RJ, Coughlin SM, Zuyderduyn SD, Jones SJM, and Marra MA. A SAGE Approach to Discovery of Genes Involved in Autophagic Cell Death. Current Biology. 2003 Feb 18;13(4):358-63.
  42. Gorski SM and Marra M. Programmed cell death takes flight: Genetic and genomic approaches to gene discovery in Drosophila. Physiological Genomics. 2002;9(2):59-69.
  43. Mirkovic I, Charish K, Gorski SM, McKnight K and Verheyen EM. Drosophila nemo is an essential gene involved in the regulation of programmed cell death. Mechanisms of Development. 2002 Nov;119(1):9-20.
  44. Gorski SM, Brachmann CB, Tanenbaum SB, and Cagan RL. Delta and Notch promote correct localization of IrreC-rst. Cell Death and Differentiation. 2000 Oct;7(10):1011-3.
  45. Tanenbaum SB*, Gorski SM*, Rusconi JC, and RL Cagan. A screen for dominant modifiers of the irreC-rst cell death phenotype in the developing Drosophila retina. Genetics. 2000 Sep;156(1):205-17. *Both authors contributed equally to this work.
  46. Nowotny P*, Gorski SM*, Han SW, Philips K, Ray WJ, Nowotny V, Jones C, Clark RF, Cagan RL and Goate AM. Post-translational Modification and Plasma Membrane Localization of the Drosophila melanogaster Presenilin. Mol Cell Neuro. 2000 Jan;15(1):88-98. *Both authors contributed equally to this work.
  47. Fitzpatrick KA, Gorski SM, Ursuliak Z and Price JV. Expression of protein tyrosine phosphatase genes during oogenesis in Drosophila melanogaster. Mechanisms of Development. 1995 Oct;53(2):171-83.
  48. Gorski SM, Adams KJ, Birch PH, Chodirker BN, Greenberg CR and Goodfellow PJ. Linkage analysis of X-linked cleft palate and ankyloglossia in Manitoba Mennonite and British Columbia Native kindreds. Human Genetics. 1994 Aug;94(2):141-8.
  49. Smith MJ, Arndt A, Gorski SM and Fajber E. The phylogeny of echinoderm classes based on mitochondrial gene arrangements. Journal of Molecular Evolution. 1993 Jun;36(6):545-54.
  50. Gorski SM, Adams KJ, Birch PH, Friedman JM and Goodfellow PJ. The gene responsible for X-linked cleft palate (CPX) in a British Columbia Native kindred is localized between PGK1 and DXYS1. Am J Human Genetics. 1992 May;50(5):1129-36.
  51. Smith MJ, Banfield DK, Doteval K, Gorski SM and Kowbel DJ. Nucleotide sequence of nine protein-coding genes and 22 tRNAs in the mitochondrial DNA of the sea star Pisaster ochraceus. Journal of Molecular Evolution. 1990;31:195-204.
  52. Smith MJ, Banfield DK, Doteval K, Gorski SM and Kowbel DJ. 1989. Gene arrangement in sea star mitochondrial DNA demonstrates a major inversion event during echinoderm evolution. Gene. 1989;76:181-85.
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