Scientific Publications
Search results for "Pleasance E"
2016/12/23
Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study.Background Gastrointestinal carcinomas are genomically complex cancers that are lethal in the metastatic setting. Whole-genome and transcriptome sequencing allow for the simultaneous characterization...
2013/08/15
Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing.Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous cancer composed of at least 2 molecular subtypes that differ in gene expression and distribution of mutations. Recently, applicatio...
2013/07/04
Comprehensive molecular characterization of clear cell renal cell carcinoma.Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for exam...
2013/05/30
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.BACKGROUND: Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet c...