Scientific Publications
Search results for "Tam A"
2013/08/01
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm.DNA methylation plays key roles in diverse biological processes such as X chromosome inactivation, transposable element repression, genomic imprinting, and tissue-specific gene expression. Sequencing-...
2013/07/04
Comprehensive molecular characterization of clear cell renal cell carcinoma.Genetic changes underlying clear cell renal cell carcinoma (ccRCC) include alterations in genes controlling cellular oxygen sensing (for example, VHL) and the maintenance of chromatin states (for exam...
2013/07/01
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.Transposable element (TE)-derived sequences comprise half of the human genome and DNA methylome and are presumed to be densely methylated and inactive. Examination of genome-wide DNA methylation statu...
2013/07/01
Complete genomic landscape of a recurring sporadic parathyroid carcinoma.Parathyroid carcinoma is a rare endocrine malignancy with an estimated incidence of less than 1 per million population. Excessive secretion of parathyroid hormone, extremely high serum calcium level, ...
2013/06/30
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells.DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germ...
2013/06/07
Complete genomic landscape of a recurring sporadic parathyroid carcinoma.Parathyroid carcinoma is a rare endocrine malignancy with an estimated incidence of less than 1 per million population. Excessive secretion of parathyroid hormone, extremely high serum calcium level, ...
2013/05/30
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.BACKGROUND: Many mutations that contribute to the pathogenesis of acute myeloid leukemia (AML) are undefined. The relationships between patterns of mutations and epigenetic phenotypes are not yet c...
2013/05/26
DNA hypomethylation within specific transposable element families associates with tissue-specific enhancer landscape.Transposable element (TE)-derived sequences comprise half of the human genome and DNA methylome and are presumed to be densely methylated and inactive. Examination of genome-wide DNA methylation statu...
2013/04/01
The genetic landscape of high-risk neuroblastoma.Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectr...
2012/04/04
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cance...