Scientific Publications
Search results for "Zeng T"
2013/07/01
Complete genomic landscape of a recurring sporadic parathyroid carcinoma.Parathyroid carcinoma is a rare endocrine malignancy with an estimated incidence of less than 1 per million population. Excessive secretion of parathyroid hormone, extremely high serum calcium level, ...
2013/06/18
Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.High-grade serous ovarian cancer (HGSC) is characterized by poor outcome, often attributed to emergence of treatment-resistant sub-clones. We sought to measure the degree of genomic diversity within p...
2013/06/07
Complete genomic landscape of a recurring sporadic parathyroid carcinoma.Parathyroid carcinoma is a rare endocrine malignancy with an estimated incidence of less than 1 per million population. Excessive secretion of parathyroid hormone, extremely high serum calcium level, ...
2012/10/26
Clonal evolution of high-grade serous ovarian carcinoma from primary to recurrent disease.High-grade serous carcinoma (HGSC) is the most common and fatal form of ovarian cancer. While most tumors are highly sensitive to cytoreductive surgery and platinum- and taxane-based chemotherapy, the...
2012/09/01
Use of mutation profiles to refine the classification of endometrial carcinomas.The classification of endometrial carcinomas is based on pathological assessment of tumour cell type; the different cell types (endometrioid, serous, carcinosarcoma, mixed, undifferentiated, and clear...
2012/08/16
Mutation discovery in regions of segmental cancer genome amplifications with CoNAn-SNV: a mixture model for next generation sequencing of tumors.Next generation sequencing has now enabled a cost-effective enumeration of the full mutational complement of a tumor genome-in particular single nucleotide variants (SNVs). Most current computational ...
2012/04/04
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.Primary triple-negative breast cancers (TNBCs), a tumour type defined by lack of oestrogen receptor, progesterone receptor and ERBB2 gene amplification, represent approximately 16% of all breast cance...
2012/01/15
Feature-based classifiers for somatic mutation detection in tumour-normal paired sequencing data.MOTIVATION: The study of cancer genomes now routinely involves using next-generation sequencing technology (NGS) to profile tumours for single nucleotide variant (SNV) somatic mutations. However, s...
2012/01/12
Identification and characterization of Hoxa9 binding sites in hematopoietic cells.The clustered homeobox proteins play crucial roles in development, hematopoiesis, and leukemia, yet the targets they regulate and their mechanisms of action are poorly understood. Here, we identified ...