Cancer Genomics: A Multi-Disciplinary Approach to the Large-Scale High-Throughput Identification of Genes Involved in Early Stage Cancers
The goal of this project is to detect cancers at an early stage to increase the chances of long term disease-free survival.
| Project Leaders | Victor Ling , Marco Marra , Connie Eaves |
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Overview
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Cancer kills one third of the Canadian population and millions of people are living with cancer. Furthermore, the number of new cases of cancer is rising at an alarming rate with a 50% increase projected over the next 15 years. The goal of this project is to detect cancers at an early stage to increase the chances of long term disease-free survival. This project will develop techniques to track how cells transform into malignancies by identifying the altered patterns of genes and proteins in the early stages of cancer. The initial research focused on lung, breast, gastric, oral, lymphoid, and myeloid malignancies. The project has found several new genes associated with lung cancer progression, 13 new genomic regions associated with prostate cancer, and 10 new mutations in gastric cancer. Gaining a better understanding of cancer progression will lead to the development of better preventative measures, screening protocols, and therapies.