Cancer transcriptome characterization using massively parallel DNA sequencing
Cancer transcriptome characterization using massively parallel DNA sequencing
| Project Leaders | Marco Marra |
|---|---|
| Project Co-Investigators | Steven Jones , Andy Mungall, Gordon Robertson |
| Project Contacts |
For all project related inquires contact: Payal Sipahimalani |
| Funding Agencies | |
| Project Web site | http://cancergenome.nih.gov/ |
TCGA
Overview
The Cancer Genome Atlas (TCGA) is an NIH-initiated, comprehensive, and coordinated effort to accelerate the understanding of the genetics of cancer using innovative genome analysis technologies. The TCGA consortium will study more than 20 tumor types and analyze thousands of samples over the next five years. Each cancer will undergo detailed genomic characterization that incorporates powerful bioinformatic and data analysis components. The TCGA project will result in the most comprehensive understanding of cancer genomes and will enable researchers to further mine the TCGA data to improve prevention, diagnosis and treatment of cancer.
Canada’s Michael Smith Genome Sciences Centre (GSC), a Canadian participant in the TCGA consortium, has been selected as one of six Genome Characterization Centers (GCCs). Its role is to identify RNA-specific changes in cancer cells. Over a period of 5 years, the GSC will be characterizing in total more than 10,000 tumor samples of cancer patients by either micro RNA (miRNA) analysis alone or in combination with RNA-Seq analysis. To optimize the interpretation of the biological information, the GSC will also provide support to the Genome Data Analysis Centers (GDAC) for RNA-specific data analysis.
The disease types that will be studied in the project include:
- acute myeloid leukemia
- bladder urothelial carcinoma
- brain glioma
- breast carcinoma
- cervical squamous cell carcinoma
- colon adenocarcinoma
- head and neck squamous cell carcinoma
- renal clear and papillary cell carcinomas
- liver carcinoma
- lung adenocarcinoma and squamous cell carcinoma
- pancreatic adenocarcinoma
- prostate adenocarcinoma
- rectal adenocarcinoma
- skin cutaneous melanoma
- stomach adenocarcinoma
- thyroid carcinoma
- endometrioid carcinoma
Recent TCGA Publications:
The Cancer Genome Atlas Research Network (2012) Comprehensive molecular portraits of human breast tumours. Nature. doi:10.1038/nature11412. Read the full article
The Cancer Genome Atlas Research Network (2012) Comprehensive genomic characterization of squamous cell lung cancers. Nature. doi:10.1038/nature11404. Read the full article
The Cancer Genome Atlas Research Network (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487(7407):330-337. Read the full article
TCGA in the news:
Findings from TCGA and their potential impact on cancer research have been featured in a number of media stories both local and international. A more comprehensive list of news articles featuring TCGA can be found on the NCI website.
For all project related inquiries please contact:
Payal Sipahimalani
Project Manager
Genome Sciences Centre
BC Cancer Agency
Email: payals@bcgsc.ca
Phone: 604-707-5900 x675432