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Bioinformatics of Mammalian Gene Expression project funded by Genome Canada

Genome Canada Funded Project

Vancouver, BC, Canada | The genome is the complement of DNA inside the nucleus of a cell. Within the genome are the genes and the regulatory elements, which are responsible for turning genes "on" or "off".

At the present time, we can identify genes that are turned on or "expressed" through a technique called gene expression profiling. We can also observe the level of activity of those genes. But we do not know much about the regulatory elements, which cause this activity. In other words, we can observe the effects of these elements but not the elements themselves. The researchers in this project propose to find these elements.

To do so, the researchers will study the human genome and the mouse genome sequences and use computer-generated comparisons to identify regions of similarities. Added to this will be information from the expression profiling studies. By means of data analysis, they will develop a list of regulatory elements; the genes upon which they have an effect; the magnitude of these effects and the tissues and developmental stages in which they are active.

This information will have important applications in gene-based therapies for cancer and other diseases.

The Genome Sequence Centre received funding for the following new projects.

Bioinformatics of Mammalian Gene Expression
Jones S, Marra M [$6.4M] | info | genome canada

A Quantitative and Comprehensive Atlas of Gene Expression in Mouse Development
Marra M, Hoodless P [$11.8M] | info | genome canada

Page last modified Aug 15, 2006