BreakFusion: targeted assembly-based identification of gene fusions in whole transcriptome paired-end sequencing data.
| Authors | Chen K, Wallis JW, Kandoth C, Kalicki-Veizer JM, Mungall KL, Mungall AJ, Jones SJ, Marra MA, Ley TJ, Mardis ER, Wilson RK, Weinstein JN & Ding L. |
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| Abstract | Despite recent progress, computational tools that identify gene fusions from next-generation whole transcriptome sequencing data are often limited in accuracy and scalability. Here, we present a software package, BreakFusion that combines the strength of reference alignment followed by read-pair analysis and de novo assembly to achieve a good balance in sensitivity, specificity and computational efficiency. AVAILABILITY: http://bioinformatics.mdanderson.org/main/BreakFusion |
| Journal Name and Citation | Bioinformatics. 2012 Jul 15;28(14):1923-4. |
| Date of Publication | 2012/07/15 |
| Publication Link | http://bioinformatics.oxfordjournals.org/content/28/14/1923.abstract |