Cancer genome-sequencing study design.
| Authors | Mwenifumbo JC & Marra MA. |
|---|---|
| Abstract | Discoveries from cancer genome sequencing have the potential to translate into advances in cancer prevention, diagnostics, prognostics, treatment and basic biology. Given the diversity of downstream applications, cancer genome-sequencing studies need to be designed to best fulfil specific aims. Knowledge of second-generation cancer genome-sequencing study design also facilitates assessment of the validity and importance of the rapidly growing number of published studies. In this Review, we focus on the practical application of second-generation sequencing technology (also known as next-generation sequencing) to cancer genomics and discuss how aspects of study design and methodological considerations - such as the size and composition of the discovery cohort - can be tailored to serve specific research aims. |
| Journal Name and Citation | Nat Rev Genet. 321-32. |
| Date of Publication | 2013/05/14 |
| Publication Link | http://www.nature.com/nrg/journal/v14/n5/pdf/nrg3445.pdf |