Defining the clonality of peripheral T cell lymphomas using RNA-seq.
| Authors | Scott D Brown, Greg Hapgood, Christian Steidl, Andrew P Weng, Kerry J Savage & Robert A Holt |
|---|---|
| Abstract | In T-cell lymphoma, malignant T cells arising from a founding clone share an identical T cell receptor (TCR) and can be identified by the over-representation of this TCR relative to TCRs from the patient's repertoire of normal T cells. Here, we demonstrate that TCR information extracted from RNA-seq data can provide a higher resolution view of peripheral T cell lymphomas (PTCLs) than that provided by conventional methods. |
| Journal Name and Citation | Bioinformatics. 2016 Dec 21. pii: btw810. doi: 10.1093/bioinformatics/btw810. [Epub ahead of print] |
| Date of Publication | 2016/12/21 |
| Publication Link | https://academic.oup.com/bioinformatics/article-lookup/doi/10.1093/bioinformatics/btw810 |