DNA hypermethylation and 1p Loss silence NHE-1 in oligodendroglioma.
| Authors | Blough MD, Al-Najjar M, Chesnelong C, Binding CE, Rogers AD, Luchman HA, Kelly JJ, Fliegel L, Morozova O, Yip S, Marra M, Weiss S, Chan JA & Cairncross JG. |
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| Abstract | Oligodendroglioma is characterized by mutations of IDH and CIC, 1p/19q loss, and slow growth. We found that NHE-1 on 1p is silenced in oligodendrogliomas secondary to IDH-associated hypermethylation and 1p allelic loss. Silencing lowers intracellular pH and attenuates acid load recovery in oligodendroglioma cells. Others have shown that rapid tumor growth cannot occur without NHE-1-mediated neutralization of the acidosis generated by the Warburg glycolytic shift. Our findings show for the first time that the pH regulator NHE-1 can be silenced in a human cancer and also suggest that pH deregulation may contribute to the distinctive biology of human oligodendroglioma. |
| Journal Name and Citation | Ann Neurol. 2012 Jun;71(6):845-9. |
| Date of Publication | 2012/06/01 |
| Publication Link | http://www.ncbi.nlm.nih.gov/pubmed?term=Silence%20NHE-1%20in%20Oligodendroglioma |