Publication Announcements

Concurrent CIC mutations, IDH mutations and 1p/19q loss distinguish oligodendrogliomas from other cancers.

This paper has been awarded the The Journal of Pathology 2012 Jeremy Jass Prize for Research Excellence in Pathology.

Published July 27th in Nature

BC Cancer Agency Researchers from the Michael Smith Genome Sciences Centre and The Centre for Lymphoid Cancer published recent results from the NIH-funded research project: Sequencing for Discovery of Candidate Mutations in Lymphoma Transcriptomes

Human T-cell repertoire analysis

Moving the field of clinical genomics toward a future of more effective diagnosis and treatment of cancers.

Scientists and engineers from BC Cancer Agency’s Genome Sciences Centre (GSC) have developed two new approaches for characterizing how the information in genes is expressed. Details of each method, known as ALEXA-Seq and Trans-ABySS, were recently published in separate papers in the journal Nature Methods. Each approach uses state-of-the-art sequencing technology to characterize transcriptomes—collections of all expressed genes. Both methods represent significant steps towards cost-effective surveying of all genetic information in a tumour.

Alternative expression analysis by RNA sequencing.

ALEXA-Seq is a method for using massively parallel paired-end transcriptome sequencing for 'alternative expression analysis.'

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver

A MORGEN project publication available online June 15, 2010.

Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor

Dr. Marianne Sadar publishes the latest results from her studies into prostate cancer treatments in the journal Cancer Cell, Vol. 17, Issue 6, 535-546, 15 June 2010.

A quality management system application to investigate and troubleshoot process failures

Predicted mutational epitopes suitable for immunological cancer control

In this meta-analysis, scientists at the Genome Sciences Centre have evaluated all known somatic mutations in human tumors for their antigenic potential.

De novo assembly of a fungus genome

The iSSAKE short read sequence assembly approach for profiling T cell metagenomes

Visualization system for comparative genomics.

De novo genome sequence assembly of a filamentous fungus using Sanger, 454 and Illumina sequence data

The completion of the Mammalian Gene Collection (MGC)

"ABySS-Explorer: Visualizing Genome Sequence Assemblies"

Genetic variants associated with susceptibility to FL

Determination of optimal microarray designs

Experimental analysis of oligonucleotide microarray design criteria to detect deletions by comparative genomic hybridization

Rapid mapping of phenotypic traits

Rapid high resolution SNP-CGH mapping in Caenorhabditis elegans.

Sintokamides A to E, chlorinated peptides from the sponge Dysidea sp. that inhibit transactivation of the N-terminus of the androgen receptor in prostate cancer cells.

Sintokamides A to E, chlorinated peptides from the sponge Dysidea sp. that inhibit transactivation of the N-terminus of the androgen receptor in prostate cancer cells.

AR and β-catenin in androgen independent prostate cancer

Crosstalk between the androgen receptor and beta-catenin in castrate-resistant prostate cancer.