Post-doctoral Fellow in the proteomic discovery of immunotherapy

The scientist will join an ongoing collaboration with Drs. John Maris (CHOP) and Poul Sorensen (Molecular Oncology, BC Cancer) to study surface protein expression in high-risk pediatric cancers by analyzing patient derived xenograft (PDX) samples. The fellow will perform laboratory research to design and interpret experiments using proteomic, molecular, biochemical, and genomic tools to thoroughly and robustly quantify changes in surface protein expression. Specifically, the candidate will develop and perform global proteomic techniques in conjunction with a variety of surface enrichment techniques to identify and evaluate specific molecular vulnerabilities in childhood cancers that would be useful for immunotherapeutic targeting. The desirable candidate should have experience in protein biochemistry, proteomic sample preparation, liquid chromatography, and/or mass spectrometry. Experience with mammalian tissue culture, enzymatic assays, recombinant protein purification, molecular biology, and mass-spectrometry based proteomics will be beneficial to the candidate.

The successful scientist will join the laboratory of Dr. Gregg Morin in Canada’s Michael Smith Genome Sciences Centre at BC Cancer. In collaboration with the laboratories of Dr. John Maris and Dr. Poul Sorensen, and the Genome Sciences Centre, the team has access to exceptional tools for next generation sequencing, bioinformatics, and advanced proteomics.

The Genome Sciences Centre provides a stimulating working environment and is located at the British Columbia Cancer Research Centre in Vancouver, one of the world’s most livable and attractive cities. 

Additional information can be obtained at Careers, www.bcgsc.ca